Dealing with cat urine accidents is a frustrating reality for many cat owners. The lingering odor and potential for staining can be incredibly challenging to manage.
That’s where best cat urine cleaners with enzymes come in, offering a specialized solution to break down the uric acid crystals that cause these persistent problems. However, not all enzymatic cleaners are created equal.
Choosing the right product is crucial for effectively eliminating odors and stains, preventing repeat offenses, and protecting your home’s surfaces. Selecting based on quality ingredients and proven effectiveness is paramount.
In this review, we explore the world of best cat urine cleaners with enzymes, guiding you towards finding the value and performance necessary to tackle these messes effectively and maintain a clean and fresh-smelling home.
IN THIS ARTICLE
Top 5 Cat Urine Cleaners With Enzymes Compared

Rocco & Roxie Stain & Odor Eliminator for Strong Odor
- Effective stain removal, safe for colors.
- Natural, organic, and chemical-free formula.
- Versatile; safe for various pets.
- Made in the USA, quality assured.
4.4/5
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Nature’s Miracle Urine Destroyer Plus for Cats
- For cat urine messes, breaks down stains fast.
- Great for refilling smaller bottles easily.
- Enzymatic formula keeps working on bio-based messes.
- Trusted brand that removes pet stains/odors.
4.6/5
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Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer
- Multipurpose cleaning for various surfaces and drains.
- Probiotics offer continuous cleaning for up to 21 days.
- Naturally breaks down waste, eliminates odors effectively.
- Leaves a light, pleasant lemon and sage fragrance.
4.5/5
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Nature’s Miracle Urine Destroyer Plus for Cats
- Effective urine destroyer for house-cats.
- Foaming aerosol for tough urine messes.
- Suitable for all life stages of cats.
- From trusted brand: Nature’s Miracle.
4.4/5
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Angry Orange Stain Remover – 32oz Enzyme Pet Cleaner – Dog & Cat Urine Destroyer and Stain Remover – Citrus Spray Cleaning Solution – Puppy Supplies
- Targets multiple pet types (cats, dogs, small animals).
- Suitable for all life stages of pets.
- Effective citrus scent for active odor control.
- Convenient 32 ounce size for repeated use.
4.2/5
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Detailed Reviews of the Best Cat Urine Cleaners With Enzymes
Rocco & Roxie Stain & Odor Eliminator for Strong Odor – Effective stain removal, safe for colors.
Check out our miracle cleaner that eliminates even the toughest odors and stains, leaving your home fresh and clean. This product is safe for indoor use and won’t harm your pets, making it ideal for households with animals. It’s powerful enough to tackle pet messes, including urine and marking, effectively removing the smell and discouraging repeat offenses.
This cleaner is a versatile solution for various surfaces, including hardwood, carpet, clothing, and furniture. It won’t stain or damage your belongings, ensuring a worry-free cleaning experience. The product’s unique formula targets the source of odors, completely eliminating them rather than simply masking them.
It’s so effective that it can even refresh garbage cans, leaving them smelling brand new. The pleasant scent of the spray is a bonus, with a light floral fragrance that dissipates quickly, leaving your home smelling clean and fresh. This cleaner provides peace of mind, knowing you have a reliable solution for any odor or stain emergency.
It’s a small investment that delivers exceptional results, making it a valuable addition to any household cleaning arsenal.
Pros
- Effective stain removal, safe for colors.
- Natural, organic, and chemical-free formula.
- Versatile; safe for various pets.
- Made in the USA, quality assured.
Cons
- Basic features
Nature’s Miracle Urine Destroyer Plus for Cats – For cat urine messes, breaks down stains fast.
My first thought was, this carpet cleaning solution is a great choice for your home cleaning needs, especially if you own a Bissell Big Green Cleaning Machine. Enjoy the refreshing and natural forest scent that will leave your carpets smelling clean and revitalized. While the bottle is designed to be durable, its size might feel a bit unwieldy for some.
However, there is an easy solution to improve the handling. By retaining the bottle’s original packaging and repurposing it, you can create a convenient “watering can” effect for pre-treating carpets. This method allows for controlled and even distribution of the solution, maximizing its effectiveness.
This cleaning solution is highly effective on various types of carpets, including indoor/outdoor varieties. It’s even capable of tackling tough situations, such as carpets affected by stagnant water. You can trust this solution to easily and effectively remove even the most stubborn dirt and odors, leaving your carpets fresh and clean.
Pros
- For cat urine messes, breaks down stains fast.
- Great for refilling smaller bottles easily.
- Enzymatic formula keeps working on bio-based messes.
- Trusted brand that removes pet stains/odors.
- Safe to use around pets and home.
Cons
- Heavy bottle is hard to manage
- Awkward bottle is hard to handle
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer – Multipurpose cleaning for various surfaces and drains.
Game-changer! Experience a remarkably fresh scent, reminiscent of Mrs. Meyer’s Lemon Verbena, that will invigorate your home.
This product is highly effective for tackling various cleaning challenges, including pet messes and general household grime. Its versatility shines through its ability to clean diverse surfaces. Whether it’s a cat pee spot on vinyl flooring or bathroom surfaces, it provides a powerful cleaning action without leaving behind any undesirable filmy residue, unlike some other products.
It can also be used as a mop solution, diluted according to package directions, for a comprehensive cleaning experience. The product’s effectiveness extends to its ability to combat unpleasant odors, even in challenging environments. The formula effectively eliminates odors associated with pet messes and summer heat/humidity, leaving your home smelling fresh and clean.
When using in enclosed spaces, particularly at stronger concentrations, ensure proper ventilation to avoid overpowering fumes. By following this simple precaution, you can enjoy the full benefits of this exceptional cleaning product.
Pros
- Multipurpose cleaning for various surfaces and drains.
- Probiotics offer continuous cleaning for up to 21 days.
- Naturally breaks down waste, eliminates odors effectively.
- Leaves a light, pleasant lemon and sage fragrance.
Cons
- Fumes can be overpowering indoors
- Good ventilation is needed indoors
Nature’s Miracle Urine Destroyer Plus for Cats – Effective urine destroyer for house-cats.
New enzyme cleaner offers superior performance in eliminating cat urine, proving to be one of the best options available. It effectively breaks down urine, even on new items like comforters, providing a reliable solution for pet owners. This product features a less offensive scent compared to other enzyme cleaners, ensuring a more pleasant experience during and after application.
Furthermore, it avoids leaving behind the strong chemical smell often associated with similar products, contributing to a fresher and cleaner environment. The cleaner’s convenient foam format makes application easy and efficient. While the spray pattern is wide, this can be easily managed by using a towel around the targeted area when treating smaller spots on upholstery or furniture.
This minor adjustment ensures precise application and prevents overspray. Overall, this enzyme cleaner is highly effective and easy to use, making it a worthwhile choice for pet owners seeking a reliable solution for eliminating cat urine odors and stains. Its superior performance, pleasant scent, and user-friendly format make it a standout product in its category.
Pros
- Effective urine destroyer for house-cats.
- Foaming aerosol for tough urine messes.
- Suitable for all life stages of cats.
- From trusted brand: Nature’s Miracle.
- Made in the USA.
Cons
- Wide spray pattern is wasteful
- Needs spot treatment caution
Angry Orange Stain Remover – 32oz Enzyme Pet Cleaner – Dog & Cat Urine Destroyer and Stain Remover – Citrus Spray Cleaning Solution – Puppy Supplies – Targets multiple pet types (cats, dogs, small animals).
My take on Angry Orange is an excellent solution for pet owners seeking to eliminate unpleasant odors and maintain a fresh-smelling home. This enzyme cleaner effectively targets and neutralizes the source of pet odors, including urine and feces, leaving your home smelling clean and revitalized. Unlike harsh chemical cleaners with overpowering scents, Angry Orange boasts a delightful citrus fragrance that is both pleasant and refreshing.
One of the key advantages of Angry Orange is its versatility, as it can be safely used on a wide range of surfaces, including carpets, floors, fabrics, furniture, upholstery, and even turf. Its easy-to-use spray nozzle allows for targeted application, and the simple instructions make the cleaning process a breeze. Simply remove pets from the area, clean up any excess mess, shake the bottle well, spray the affected area from about 12 inches away, wipe away any excess, and let it dry.
Angry Orange is not only effective at eliminating odors but also safe for use in homes with pets. Its quick-drying formula prevents discoloration and leaves carpets feeling soft and clean. The initial strong orange scent gradually fades, leaving a subtle and pleasant fragrance that will make your home inviting.
Overall, Angry Orange is a highly recommended product for pet owners who want to maintain a clean and fresh-smelling home without resorting to harsh chemicals or unpleasant cleaning odors. Its versatility, ease of use, and delightful fragrance make it a must-have for everyday clean-up and deep cleaning tasks.
Pros
- Targets multiple pet types (cats, dogs, small animals).
- Suitable for all life stages of pets.
- Effective citrus scent for active odor control.
- Convenient 32 ounce size for repeated use.
- From a reputable manufacturer: Genesis BioSciences.
Cons
- Strong initial scent may bother some
- May need repeat applications at times
Buying Guide: What to Look For in a Cat Urine Cleaners With Enzymes
Understanding Enzymatic Cat Urine Cleaners
Enzymatic cleaners are specifically designed to tackle the unique challenges of cat urine. Unlike regular cleaners that simply mask odors, enzymatic cleaners contain enzymes that break down the uric acid crystals found in cat urine. These crystals are the primary source of the lingering odor. The best cat urine cleaners with enzymes effectively digest these crystals, completely eliminating the odor instead of just covering it up. This is crucial for preventing your cat from re-offending in the same spot.
Key Features to Consider
When choosing the best cat urine cleaners with enzymes, several factors come into play. First, consider the formula. Is it safe for your pets and family? Look for non-toxic, biodegradable options. Second, assess its effectiveness. Read reviews and look for products that specifically target cat urine. Third, consider the surface you’ll be cleaning. Some cleaners are better suited for carpets, while others are effective on hard surfaces. Finally, consider the scent. Some cleaners have strong fragrances that may be overwhelming.
Types of Enzymatic Cleaners
There are various types of enzymatic cat urine cleaners available. Some are sprays, ideal for spot cleaning. Others are concentrated formulas that need to be diluted, making them cost-effective for larger areas. Foaming aerosols are particularly effective for penetrating deep into carpets and upholstery. Some also contain probiotics for continuous cleaning. The best cat urine cleaners with enzymes are versatile and can be used on a variety of surfaces.
Application and Usage
Proper application is crucial for the effectiveness of enzymatic cat urine cleaners. Always follow the manufacturer’s instructions. Generally, you’ll need to saturate the affected area thoroughly to ensure the enzymes reach all the urine crystals. Allow the cleaner to sit for the recommended time, usually several minutes to hours, to allow the enzymes to work. Blot up the excess liquid and let the area air dry. For stubborn stains and odors, repeat the process.
Frequently Asked Questions about Cat Urine Cleaners With Enzymes
What makes enzymatic cleaners better than regular cleaners for cat urine?
Enzymatic cleaners contain enzymes that break down the uric acid crystals in cat urine, which are the primary cause of the lingering odor. Regular cleaners only mask the smell, failing to eliminate the source. The best cat urine cleaners with enzymes completely digest these crystals, effectively removing the odor and preventing your cat from re-offending in the same spot. They offer a long-term solution compared to the temporary fix of standard cleaners.
Are enzymatic cleaners safe for my pets and family?
Most enzymatic cleaners are formulated to be safe for pets and humans when used as directed. However, it’s crucial to read the label carefully and choose products that are non-toxic, biodegradable, and free of harsh chemicals. Ensure the area is well-ventilated during and after application. Keep pets and children away from the treated area until it is completely dry. The best cat urine cleaners with enzymes prioritize safety without compromising effectiveness.
How long does it take for enzymatic cleaners to work?
The time it takes for an enzymatic cleaner to work depends on the severity of the stain and odor, as well as the specific product. Generally, you should allow the cleaner to sit on the affected area for several minutes to hours, as recommended by the manufacturer. For stubborn stains, you may need to repeat the application. Patience is key, as the enzymes need time to break down the urine crystals effectively. The best cat urine cleaners with enzymes will provide clear instructions.
Can I use enzymatic cleaners on all types of surfaces?
Enzymatic cleaners are generally safe for use on various surfaces, including carpets, upholstery, hard floors, and clothing. However, it’s always a good idea to test the cleaner on an inconspicuous area first to ensure it doesn’t cause any discoloration or damage. Some cleaners are specifically formulated for certain surfaces, so choose a product that is appropriate for the area you need to clean. The best cat urine cleaners with enzymes are versatile and safe for multiple surfaces.
Will enzymatic cleaners remove old cat urine stains and odors?
Enzymatic cleaners can be effective at removing old cat urine stains and odors, but it may require multiple applications and longer soaking times. Older stains have had more time to penetrate deeper into the fibers, making them more difficult to break down. Saturate the area thoroughly and allow the cleaner to sit for an extended period. The best cat urine cleaners with enzymes are designed to tackle even the most stubborn stains and odors.
What is the best way to apply an enzymatic cleaner?
The best way to apply an enzymatic cleaner is to first blot up any excess urine with a clean cloth or paper towel. Then, saturate the affected area thoroughly with the cleaner, ensuring it reaches all the urine crystals. Allow the cleaner to sit for the recommended time, usually several minutes to hours. Blot up the excess liquid and let the area air dry. For stubborn stains and odors, repeat the process. The best cat urine cleaners with enzymes require proper application for optimal results.
Are there any natural or organic enzymatic cleaners available?
Yes, there are natural and organic enzymatic cleaners available that are made with plant-based enzymes and other natural ingredients. These cleaners are a great option for pet owners who are concerned about using harsh chemicals in their homes. Look for products that are certified organic or that list their ingredients clearly. The best cat urine cleaners with enzymes often come in natural formulations.
What should I do if the enzymatic cleaner doesn’t completely remove the odor?
If the enzymatic cleaner doesn’t completely remove the odor after the first application, repeat the process. It may take multiple applications to fully break down all the urine crystals, especially for older stains. Ensure you are saturating the area thoroughly and allowing the cleaner to sit for the recommended time. If the odor persists, consider using a black light to identify any hidden urine spots that you may have missed. The best cat urine cleaners with enzymes may require multiple attempts on severe cases.
Can I use an enzymatic cleaner in my washing machine?
Yes, some enzymatic cleaners can be used in washing machines to remove cat urine odors from clothing and bedding. Check the product label to ensure it is safe for use in washing machines and follow the manufacturer’s instructions. Use the appropriate amount of cleaner for the load size and wash the items on a cold or warm cycle. Avoid using hot water, as it can set the stain and odor. The best cat urine cleaners with enzymes offer versatility for laundry applications.
How do probiotics enhance the effectiveness of enzymatic cleaners?
Probiotics in enzymatic cleaners work by consuming any remaining urine residue after the initial enzymatic breakdown. This provides continuous cleaning action, inhibiting the growth of odor-causing bacteria and preventing the odor from returning. The probiotics essentially outcompete the harmful bacteria, creating a healthier environment. The best cat urine cleaners with enzymes sometimes include probiotics for enhanced and prolonged odor control.
Conclusion: The Final Verdict
After careful consideration of all the options, we believe the Rocco & Roxie Stain & Odor Eliminator for Strong Odor stands out as the best overall choice for most users. It offers an excellent balance of features, performance, and value. Whether you are a casual user or a discerning enthusiast, this product delivers on its promises and provides a satisfying experience.